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 ORIGINAL ARTICLE
Year : 2017  |  Volume : 19  |  Issue : 86  |  Page : 24--30

The Effects of Acoustic White Noise on the Rat Central Auditory System During the Fetal and Critical Neonatal Periods: A Stereological Study


1 Department of Physiology, Faculty of Biological Sciences and Technology, Shahid Beheshti University, Tehran; Department of Animal Sciences, College of Agriculture, Shiraz University, Shiraz, Iran
2 Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz; Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3 Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Animal Sciences, College of Agriculture, Shiraz University, Shiraz, Iran
6 Department of Physiology, Faculty of Biological Sciences and Technology, Shahid Beheshti University, Tehran, Iran
7 Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Correspondence Address:
Mohammad Reza Namavar
Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, P.O. Box 71345-1945, Shiraz
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1463-1741.199239

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Aim: To evaluate the effects of long-term, moderate level noise exposure during crucial periods of rat infants on stereological parameters of medial geniculate body (MGB) and auditory cortex. Materials and Methods: Twenty-four male offspring of 12 pregnant rats were divided into four groups: fetal-to-critical period group, which were exposed to noise from the last 10 days of fetal life till postnatal day (PND) 29; fetal period group that exposed to noise during the last 10 days of fetal life; critical period group, exposed to noise from PND 15 till PND 29, and control group. White noise at 90 dB for 2 h per day was used. Statistical Analysis Used: Variance for variables was performed using Proc GLM followed by mean comparison by Duncan’s multiple range test. Results: Numerical density of neurons in MGB of fetal-to-critical period group was lower than control group. Similar results were seen in numerical density of neurons in layers IV and VI of auditory cortex. Furthermore, no significant difference was observed in the volume of auditory cortex among groups, and only MGB volume in fetal-to-critical period group was higher than other groups. Estimated total number of neurons in MGB was not significantly different among groups. Conclusion: It seems necessary to prevent long-term moderate level noise exposure during fetal-to-critical neonatal period.






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