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Year : 2014  |  Volume : 16  |  Issue : 70  |  Page : 149--156

Protective effect of unilateral and bilateral ear plugs on noise-induced hearing loss: Functional and morphological evaluation in animal model

Dong-Kee Kim, Yooyeon Park, Sang-A Back, Hong Lim Kim, Hyu Eun Park, Kyoung-Ho Park, Sang Won Yeo, Shi-Nae Park 
 Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea

Correspondence Address:
Shi-Nae Park
Department of Otolaryngology-Head & Neck Surgery, Seoul St. Mary«SQ»s Hospital, 505 Banpo-dong, Seocho-gu, Seoul 137-701
Korea

The aim of the following study is to evaluate immediate protective effect of ear plug from noise morphologically and functionally. An 1-month aged 29 male C57BL/6 mice. Subjects were divided into four groups as normal control(G1), bilaterally plugged group (G2), unilaterally plugged group (G3) and noise control group (G4) and later 3 groups were exposed to 110 sound pressure level white noise for 60 min. Immediately after noise exposure, audiologic tests were performed and cochlear morphology and expression levels of a-synuclein in the cochlea were investigated. There were no functional changes in G2 and plugged ears of G3 after noise exposure, whereas unplugged ears of G3 and G4 showed significant hearing loss. In morphological study, there were a significant degeneration of the organ of Corti and mean number and diameter of efferent buttons, in unplugged ears of G3 and G4. Plugged ears of G3 also showed mild changes in morphological study. Reduction of a-synuclein was observed at the efferent terminals or cochlear extracts after noise exposure. The protective effect of ear plug on noise exposure was proven morphologically and functionally in the animal model of noise-induced hearing loss. Further study on cellular or ultrastructural level with ear plug will be needed to reveal more precise mechanism.


How to cite this article:
Kim DK, Park Y, Back SA, Kim HL, Park HE, Park KH, Yeo SW, Park SN. Protective effect of unilateral and bilateral ear plugs on noise-induced hearing loss: Functional and morphological evaluation in animal model.Noise Health 2014;16:149-156


How to cite this URL:
Kim DK, Park Y, Back SA, Kim HL, Park HE, Park KH, Yeo SW, Park SN. Protective effect of unilateral and bilateral ear plugs on noise-induced hearing loss: Functional and morphological evaluation in animal model. Noise Health [serial online] 2014 [cited 2020 Jul 5 ];16:149-156
Available from: http://www.noiseandhealth.org/article.asp?issn=1463-1741;year=2014;volume=16;issue=70;spage=149;epage=156;aulast=Kim;type=0