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Figure 7. Schematic diagram of the PMCA2 knockout phenotype. Otocadherin is normal in structure but is not able to form strong ball-and-socket connections between diamers because the PMCA2 pump is not present to maintain the endolymph calcium concentration. Stereocilia may also be weakened from toxicity of calcium which cannot be removed from cell interior.

Figure 7. Schematic diagram of the PMCA2 knockout phenotype. Otocadherin is normal in structure but is not able to form strong ball-and-socket connections between diamers because the PMCA2 pump is not present to maintain the endolymph calcium concentration. Stereocilia may also be weakened from toxicity of calcium which cannot be removed from cell interior.