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Figure 1: Schematic diagram showing how aminoglycosides, such as gentamicin, may enter hair cells and supporting cells across their lumenal (endolymphatic) membranes. Gentamicin may enter endolymph via transport from lateral wall capillaries, or directly from the perilymphatic compartments. Alternatively, like K+, gentamicin may be passaged from perilymph via supporting cells and fibrocytes (F) to the stria vascularis (S) via gap junctions and transported into marginal cells by as-yet-unidentified transporters and thence into endolymph (see also Figure 2). Diagram is not to scale.

Figure 1: Schematic diagram showing how aminoglycosides, such as gentamicin, may enter hair cells and supporting cells across their lumenal (endolymphatic) membranes. Gentamicin may enter endolymph via transport from lateral wall capillaries, or directly from the perilymphatic compartments. Alternatively, like K+, gentamicin may be passaged from perilymph via supporting cells and fibrocytes (F) to the stria vascularis (S) via gap junctions and transported into marginal cells by as-yet-unidentified transporters and thence into endolymph (see also Figure 2). Diagram is not to scale.