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Figure 2: Schematic diagram postulating how gentamicin cross the strial blood-labyrinth barrier into endolymph. Gentamicin could clear directly from endothelial cells (E) into the intra-strial space, or passage into intermediate (I) cells via gap junctions from endothelial cells, or basal (B) cells and fibrocytes (F). Once in intermediate cells, gentamicin could then be cleared into the intra-strial space. An unidentified mechanism transports gentamicin into marginal (M) cells, where they could passively flow down the electrochemical gradient into endolymph, via non-selective cation channels for example. Diagram is not to scale.

Figure 2: Schematic diagram postulating how gentamicin cross the strial blood-labyrinth barrier into endolymph. Gentamicin could clear directly from endothelial cells (E) into the intra-strial space, or passage into intermediate (I) cells via gap junctions from endothelial cells, or basal (B) cells and fibrocytes (F). Once in intermediate cells, gentamicin could then be cleared into the intra-strial space. An unidentified mechanism transports gentamicin into marginal (M) cells, where they could passively flow down the electrochemical gradient into endolymph, via non-selective cation channels for example. Diagram is not to scale.