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 REVIEW ARTICLE
Year : 2000  |  Volume : 3  |  Issue : 9  |  Page : 1--10

The role of glutathione in carboplatin ototoxicity in the chinchilla


Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, USA

Correspondence Address:
D Henderson
Center for Hearing and Deafness, State University of New York at Buffalo, 3435 Main Street, 215 Parker Hall, Buffalo, New York 14214
USA
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Source of Support: None, Conflict of Interest: None


PMID: 12689438

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The role of glutathione in carboplatin ototoxicity was investigated in the chinchilla. Chinchillas hearing was tested with both distortion product otoacoustic emissions (DPOAE) and evoked potentials recorded from a chronic electrode in the inferior colliculus (IC). All subjects had an osmotic pump fitted to their right ear and it received buthionine sulfoximine (BSO) at a dose of 15 mM delivered at 5 ml per hour for 14 days. A group (N=4) was given a double dose of carboplatin (25 mg/kg i.p. for 2 days). The pump was implanted three days before the carboplatin dose. The BSO treated ears showed a greater loss in both evoked potential and DPOAE measures, as well as substantially fewer missing hair cells. The results implicate reactive oxygen species (ROS) as a common factor in ototoxic reactions because suppression of glutathione antioxidant leads to greater ototoxic reactions.






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