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Year : 2000  |  Volume : 3  |  Issue : 9  |  Page : 23--32

Noise-induced hearing loss in rats

1 Hearing Research Laboratories, University Medical Centre, Utrecht; TNO Food and Nutrition Research,Zeist, Netherlands
2 Hearing Research Laboratories, University Medical Centre, Utrecht, Netherlands
3 TNO Food and Nutrition Research,Zeist, Netherlands

Correspondence Address:
Natalie LM Cappaert
Hearing Research Laboratories, University Medical Centre, Room G.02.531, Heidelberglaan 100, NL-3584 CX, Utrecht
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Source of Support: None, Conflict of Interest: None

PMID: 12689440

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The effect of noise exposure on the auditory system is well known from animal studies. However, most of the studies concern short-term exposure conditions. The purpose of the present research was to find the dose-effect curve for hearing loss in rats following 5 days of noise exposure. Three groups of eight Wag/Rij rats were exposed to broad band noise at levels of 90, 100 and 110 dB SPL for 8 hours/day and 5 consecutive days. An additional group of eight rats served as the control group. Between three and seven weeks after the exposure, hearing was tested by electrocochleography (CAP) and distortion product otoacoustic emissions (DPOAE). Subsequently, the cochlea were morphologically examined. Only the highest two exposure levels affected hearing. The DPOAE growth curves at 4, 8 and 16 kHz and the CAP growth curves at 4, 8, 12, 16 and 24 kHz were affected after the 110 dB SPL broad band noise. After the 100 dB SPL noise, only the 12 kHz CAP growth curve was affected. At the light microscopic level, OHC damage was not detected in this study.


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