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Year : 2014  |  Volume : 16  |  Issue : 71  |  Page : 223--227

Comparison of the effects of N-acetyl-cysteine and ginseng in prevention of noise induced hearing loss in male textile workers


1 Department of Audiology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
2 Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
3 Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Occupational Medicine, Institute of Salamat Gostar of Occupational Medicine, Tehran, Iran

Correspondence Address:
Dr. Yones Lotfi
Department of Audiology, University of Social Welfare and Rehabilitation Sciences, Velenjak, P.O. Box 1985713834, Tehran
Iran
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Source of Support: This study was funded by University of Social Welfare and Rehabilitation Sciences,, Conflict of Interest: None


DOI: 10.4103/1463-1741.137057

Clinical trial registration IRCT201301158698N9.

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Previous studies revealed the role of antioxidant agents in prevention of noise induced hearing loss (NIHL). The aim of this study was to compare the protective effect of N-acetyl-cysteine (NAC) and ginseng on protection of NIHL in textile workers exposed to continuous noise in daily working. In this study, 48 participants were randomly allocated to three groups; Group I received NAC 1200 mg/day, Group II received ginseng 200 mg/day, and Group III (control group) received no supplement. Pure tone audiometry and high frequency audiometry were performed preshift before and after 14 days (on day 15). Linear regression analysis results showed reduced noise-induced temporary threshold shift (TTS) for NAC and ginseng groups at 4, 6 and 16 kHz (P < 0.001) in both ears. Furthermore, the protective effects were more prominent in NAC than ginseng. Our results show that NAC and ginseng can reduce noise induced TTS in workers exposed to occupational noise. Further studies are needed to prove antioxidants benefits in hearing conservation programs.






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