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 ORIGINAL ARTICLE
Year : 2020  |  Volume : 22  |  Issue : 106  |  Page : 63--69

Adrenergic alpha-2 receptor antagonists cease augmented oxidation of plasma proteins and anxiety of rats caused by chronic noise exposure


1 Department of Medical Chemistry Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
2 Department of Pathophysiology Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
3 Science Research Center (SRC), Yerevan State Medical University after M. Heratsi, Yerevan, Armenia

Correspondence Address:
Ashkhen Lyova Manukyan
Assistant Professor, Department of Medical Chemistry Yerevan State Medical University after M. Heratsi, Galshoyan Str., 36/38, 0079, Yerevan
Armenia
Mariam Varos Manukyan
Assistant Professor, Galshoyan Str., 36/38, 0079, Yerevan
Armenia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/nah.NAH_31_19

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Background: Noise is one of the environmental factors, which is considered as a powerful stressor for the organism. Generally, the acoustic stress affects the behavior and physiological state of humans and animals. Aims: The goal of this study is to investigate the relationship between chronic noise exposure and the effects of adrenergic alpha-2 receptor antagonists, beditin and mesedin, on the anxiety and oxidation of plasma proteins and fibrinogen in rats. Methods: The experiments were carried out on non-linear albino male rats, divided into four groups (six animals in each): 1. Healthy controls 2. Exposed to noise of a level 91 dB(A), eight hours daily, during 7, 30 and 60 days; 3. Injected with 2 mg/kg of beditin (2-(2-amino-4-thiazolyl)-1,4-benzodioxane hydrochloride)); 4. Injected with 10 mg/kg mesedin (2-(2-methyl-amino-thiozolyl)-1,4-benzodioxane hydrochloride). For evaluating the cognitive impairment, the Any-maze test was applied. The level of carbonylation of proteins was assessed by reaction with 2,4-dinitrophenylhydrazine, spectrophotometrically. Results: Chronic noise decreased locomotor activity and increased anxiety and oxidation of plasma protein and fibrinogen. Intensity of these changes were dependent on the duration of noise exposure. Conclusion: The Alpha 2 adrenoblockers alleviate oxidative modification of plasma proteins and reduce the cognitive impairment caused by chronic exposure to noise.






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