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Figure 6. (A) Cochleogram from a chinchilla treated with 200 mg/kg of carboplatin. Note massive IHC loss throughout most of cochlea and OHC loss that decreases from base to apex. (B) DPOAE input/output functions (f1=8 kHz, f2 = 9.6 kHz, L1=L2) measured precarboplatin and 3-months postcarboplatin. Dashed line represents noise floor of the measurement system. Note complete loss of DPOAE postcarboplatin. (C) DPOAE input/output functions (f1=1 kHz, f2 = 1.2 kHz, L1=L2) measured pre-carboplatin and 3-months post-carboplatin. Dashed line represents noise floor of the measurement system. DPOAE shows only slight reduction postcarboplatin.

Figure 6. (A) Cochleogram from a chinchilla treated with 200 mg/kg of carboplatin. Note massive IHC loss throughout most of cochlea and OHC loss that decreases from base to apex. (B) DPOAE input/output
functions (f1=8 kHz, f2 = 9.6 kHz, L1=L2) measured precarboplatin and 3-months postcarboplatin.
Dashed line represents noise floor of the measurement system. Note complete loss of DPOAE postcarboplatin. (C) DPOAE input/output functions (f1=1 kHz, f2 = 1.2 kHz, L1=L2) measured pre-carboplatin and 3-months post-carboplatin. Dashed line represents noise floor of the measurement system. DPOAE shows only slight reduction postcarboplatin.