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Figure 1. The response of plasma ACTH and -cortisol to the injection of 100 g human corticotropin releasing hormone (CRH) at zero time in 12 healthy subjects (shaded area, means standard deviation) and in 12 patients with Cushing's disease due to a pituitary micoradenoma (filled dots). Patients with adrenal tumors would have unmeasurably low plasma ACTH and would not respond to CRH, while those with an ectopic source of ACTH would have elevated ACTH unresponsive to CRH injection.

Figure 1. The response of plasma ACTH and -cortisol to the injection of 100 g human corticotropin
releasing hormone (CRH) at zero time in 12 healthy subjects (shaded area, means  standard deviation)
and in 12 patients with Cushing's disease due to a pituitary micoradenoma (filled dots). Patients with
adrenal tumors would have unmeasurably low plasma ACTH and would not respond to CRH, while
those with an ectopic source of ACTH would have elevated ACTH unresponsive to CRH injection.